The extracellular matrix does more than just blanket cells; it also provides informational cues which affect a variety of developmental and cellular maintenance activities. The constituents of the matrix provide the fabric for cell motility and cell shape as well as anchorage sites for bioactive factors which directly affect the cell's developmental pattern or mitotic activity. The influence of the extracellular matrix is controlled by the cell's responsiveness to these complex signals. The same matrix component, for example hyaluronic acid, can (...) have completely different effects depending on the cell's lineage and developmental history. The functional interaction between the extracellular matrix and specific cell surface receptors provides cues which affect the control of development and the maintenance and aging events that affect specific cells and tissues. (shrink)

Although bone development during embryogenesis and bone repair after injury have a number of features which appear similar, they are distinctly different processes which involve separate controlling elements and cuing parameters. Repair of bone is influenced by bioactive factors which reside in bone itself; some of these factors are not present when embryonic mesenchymal cells first differentiate. For example, a bone protein which induces the conversion of mesenchymal cells into cartilage cells is not present in the embryo at the site (...) where cartilage first differentiates into the anlagen for future bone. Ultimately, the sequence of cellular and molecular events which controls the success of bone repair is dependent on the prior embryologic and developmental packaging of bioactive factors into bone and the release of these factors at a bone break site. The success of the reparative events depends not only upon the release of these bone‐derived factors but also on systemic factors and the identity and numbers of responding cells at the repair site. (shrink)

Volume 16 of Progress in Self Psychology, _How Responsive Should We Be_, illuminates the continuing tension between Kohut's emphasis on the patient's subjective experience and the post-Kohutian intersubjectivists' concern with the therapist's own subjectivity by focusing on issues of therapeutic posture and degree of therapist activity. Teicholz provides an integrative context for examining this tension by discussing affect as the common denominator underlying the analyst's empathy, subjectivity, and authenticity. Responses to the tension encompass the stance of intersubjective contextualism, advocacy of (...) "active responsiveness," and emphasis on the thorough-going bidirectionality of the analytic endeavor. Balancing these perspectives are a reprise on Kohut's concept of prolonged empathic immersion and a recasting of the issue of closeness and distance in the analytic relationship in terms of analysis of "the tie to the negative selfobject." Additional clinical contributions examine severe bulimia and suicidal rage as attempts at self-state regulation and address the self-reparative functions that inhere in the act of dreaming. Like previous volumes in the series, volume 16 demonstrates the applicability of self psychology to nonanalytic treatment modalities and clinical populations. Here, self psychology is brought to bear on psychotherapy with placed children, on work with adults with nonverbal learning disabilities, and on brief therapy. Rector's examination of twinship and religious experience, Hagman's elucidation of the creative process, and Siegel and Topel's experiment with supervision via the internet exemplify the ever-expanding explanatory range of self-psychological insights. (shrink)

A collection of thoughtul presentations on transference and countertransference highlights _The Realities of Transference_, Volume 6 in the Progress in Self Psychology series. The selfobject transferences receive special attention. Elsewhere in this volme, selfobject phenomena are examined in relation to the process of working through, the origins of ambition, the psychology of addiction, the psychodynamic consequences of AIDS, and creativity. An exploration of the selfobjects of the second half of life offers new insight into later development.

Pierre Hadot, whose inaugural lecture to the chair of the History of Hellenistic and Roman Through at the Collège de France we are publishing here, is one of the most significant and wide-ranging historians of ancient philosophy writing today. His work, hardly known in the English-reading world except among specialists, exhibits that rare combination of prodigious historical scholarship and rigorous philosophical argumentation that upsets any preconceived distinction between the history of philosophy and philosophy proper. In addition to being the translator (...) and author of monographs on Plotinus, Vitorinus, Porphyry, and many others, Hadot’s most important general philosophical work is entitled Exercises spirituels et philosophie antique.1 Combined with detailed studies of Socrates and Marcus Aurelius, this work presents a history of spiritual exercises from Socrates to early Christianity, an account of their decline in modern philosophy, and a discussion of the different conceptions of philosophy that have companied the trajectory and fate of the theory and practice of spiritual exercises. Hadot’s “Forms of Life and Forms of Discourse in Ancient Philosophy” provides an overview of his major themes and preoccupations, and gives some indication of the historical scope of his work. This lecture also illuminates the methodological problems one faces in studying the history of thought, especially problems concerning the evolution, reinterpretation, and even misunderstanding of the meaning and significance of philosophical terminology. In this brief introduction, I can do no more than attempt to provide a context for Hadot’s inaugural lecture, by way of summary of his major work, and, more specifically for reader’s of Critical Inquiry, to sketch the profound importance that Hadot’s writings had for the last works of Michel Foucault. Arnold I. Davidson, executive editor of Critical Inquiry, is associate professor of philosophy and a member of the Committees on the Conceptual Foundations of Science and General Studies in the Humanities at the University of Chicago. He introduced and edited the “Symposium on Heidegger and Nazism” . He is currently working on the history of horror as it relates to the epistemology of norms and deviations. (shrink)

Some years ago a collection of historical and philosophical essays on sex was advertised under the slogan: Philosophers are interested in sex again. Since that time the history of sexuality has become an almost unexceptionable topic, occasioning as many books and articles as anyone would ever care to read. Yet there are still fundamental conceptual problems that get passed over imperceptibly when this topic is discussed, passed over, at least in part, because they seem so basic or obvious that it (...) would be time badly spent to worry too much about them. However, without backtracking toweard this set of problems, one will quite literally not know what one is writing the history of when one writes a history of sexuality.An excellent example of some of the most sophisticated current writing in this field can be found in Western Sexuality, a collection of essays that resulted from a seminar conducted by Philippe Ariès at the Ecole des Hautes Etudes en Sciences Sociales in 1979-80.1 As one would expect, Western Sexuality is characterized by a diversity of methodological and historiographical approaches—social history, intellectual history, cultural history , historical sociology, the analysis of literary texts, and that distinctive kind of history practiced by Michel Foucault and also in evidence in the short essay by Paul Veyne. One perspective virtually absent from this collection is the history of science, and since I believe that the history of science has a decisive and irreducible contribution to make to the history of sexuality, it is not accident that I am going to focus on that connection. But the history of sexuality is also an area in which one’s historiography or implicit epistemology will stamp, virtually irrevocably, one’s first-order historical writing. It is an arena in which philosophical and historical concerns inevitably run into one another. 1. Philippe Ariès and Adnré Béjin, eds., Western Sexuality: Practice and Percept in Past and Present Times . Arnold I. Davidson, a coeditor of Critical Inquiry, is assistant professor of philosophy and member of the Committees on General Studies in the Humanities and on the Conceptual Foundations of Science at the University of Chicago. His previous contribution to Critical Inquiry, “How to Do the History of Psychoanalysis: A Reading of Freud’s Three Essays on the Theory of Sexuality,” appeared in the Winter 1987 issue. (shrink)

Without access to Michel Foucault’s courses, it was extremely difficult to understand his reorientation from an analysis of the strategies and tactics of power immanent in the modern discourse on sexuality (1976) to an analysis of the ancient forms and modalities of relation to oneself by which one constituted oneself as a moral subject of sexual conduct (1984). In short, Foucault’s passage from the political to the ethical dimension of sexuality seemed sudden and inexplicable. Moreover, it was clear from his (...) published essays and interviews that this displacement of focus had consequences far beyond the specific domain of the history of sexuality. Security, Territory, Population (Foucault, 2007) contains a conceptual hinge, a key concept, that allows us to link together the political and ethical axes of Foucault’s thought. Indeed, it is Foucault’s analysis of the notions of conduct and counter-conduct in his lecture of 1 March 1978 that seems to me to constitute one of the richest and most brilliant moments in the entire course. It is astonishing, and of profound significance, that the autonomous sphere of conduct has been more or less invisible in the history of modern (as opposed to ancient) moral and political philosophy. This article argues that a new attention should be given to this notion, both in Foucault’s work and more generally. (shrink)

Through the thickets of recent debates, I take two facts as clear enough starting points. The first is that Heidegger’s participation in National Socialism, and especially his remarks and pronouncements after the war, were, and remain, horrifying. The second is that Heidegger remains of the essential philosophers of our century; Maurice Blanchot testifies for several generations when he refers to the “veritable intellectual shock” that the reading of Being and Time produced in him.5 And Emmanuel Levinas, not hesitating to express (...) his reservations about Heidegger, can nevertheless bring himself to say that a person “who undertakes to philosophize in the twentieth century cannot not have gone through Hiedegger’s philosophy, even to escape it.”6 In this century, perhaps only Ludwig Wittgenstein has had a comparable impact and influence on philosophy. I do not mean to deny that one can reject the over seventy volumes of Heidegger’s Gesamtausgabe as worthless, that one can, as with Wittgenstein, find that his work is obscure, indulgent, impossible to read, that nothing in it contributes to philosophy. But both Heidegger and Wittgenstein write in anticipation of this reaction, recognizing that their desires, differently articulated, to overcome philosophy will help to determine how their writing is received. Stanley Cavell’s characterization of Wittgenstein’s Philosophical Investigations describes Heidegger as well:Philosophical Investigations, like the major modernist works of the past century at least, is, logically speaking, esoteric. That is, such works seek to split their audience into insiders and outsiders ; hence they create the particular unpleasantness of cults ; hence demand for their sincere reception the shock of conversion.7When combined with Heidegger’s political engagement, the particular unpleasantness of cults and indifference are more than joined. Thus it can seem as though one must either exculpate Heidegger, explain away his relation to Nazism as an aberration from the outside, or reject his thought entirely, declare that his books should no longer be read. In an attempt to begin to confront these issues, Critical Inquiry is publishing this symposium. 5. Maurice Blanchot, “Thinking the Apocalypse: A Letter from Maurice Blanchot to Catherine David,” trans. Paula Wissing, p. 479 of this issue.6. Emmanuel Levinas, Ethics and Infinity: Conversations with Philippe Nemo, trans. Richard A. Cohen , p. 42. See also the last line of Gadamer, “ ‘Back from Syracuse?’ “ p. 430.7. Stanley Cavell, The Claim of Reason: Wittgenstein, Skepticism, Morality, and Tragedy , p. xvi; hereafter abbreviated CR. Arnold I. Davidson, a coeditor of Critical Inquiry, is associate professor of philosophy and member of the Committees on General Studies in the Humanities and on the Conceptual Foundations of Science at the University of Chicago. His most recent contribution to Critical Inquiry is “Sex and the Emergence of Sexuality”. (shrink)

A special section of papers on the evolution, current status, and future development of self psychology highlights _The Evolution of Self Psychology_, volume 7 of the Progress in Self Psychology series. A critical review of recent books by Basch, Goldberg, and Stolorow et al. is part of this endeavor. Theoretical contributions to Volume 7 examine self psychology in relation to object relations theory and reconsider the relationship of psychotherapy to psychoanalysis. Clinical contributions deal with an intersubjective perspective on countertransference, the (...) trauma of incest, and envy in the transference. (shrink)

During the last several years, we have witnessed a reopening of questions concerning National Socialism whose full scope and implications have yet to be determined. The Historikerstreit has provoked new discussions of the problem of the specificity or uniqueness of Auschwitz. While raising general methodological issues about the nature of historical explanation and understanding, the Historikerstreit has also revolved around specific questions concerning the role of moral concepts and memory in assessing National Socialism.1 Disclosures about Paul de Man’s wartime writings (...) and further examination of Martin Heidegger’s involvement with National Socialism have led to broader consideration of the relations among philosophy, theory, and politics, and have forced us to rethink the problem of intellectual responsibility with renewed urgency.2 These and related topics were at the center of a major international conference, “Nazism and the Final Solution,” organized by Saul Friedländer last April, which took as its organizing theme the limits of ethical, aesthetic, and historical representation of the Final Solution.3In light of these continuing discussions, we are publishing two remarkable essays written during the early years of National Socialism. To the often-posed challenge, how could one be expected to respond lucidly to Nazism in the early 1930s?, these essays by Robert Musil and Emmanuel Levinas constitute, by the sheer power of their insights, decisive answers. Although significantly different in approach, these essays show not only that one could recognize the reality of National Socialism as it was coming to power, but indicate further that analyses of permanent value could be formulated virtually from the beginning. Musil and Levinas serve to remind us concretely of the capabilities of the human mind and of its responsibilities—capabilities and responsibilities that even the most severe political circumstances need not overwhelm. 1. For documents from and discussion of the Historikstreit, see the special issue of New German Critique 44 .2. On Paul de Man, see Critical Inquiry 14 : 590-652, and Critical Inquiry 15 : 704-44, 764-873. On Martin Heidegger, see Critical Inquiry 15 : 407-88.3. The proceedings of this conference are forthcoming. Arnold I. Davidson, executive editor of Critical Inquiry and associate professor of philosophy at the University of Chicago, is currently Marta Sutton Weeks Fellow at the Stanford Humanities Center. (shrink)

Volume 13 provides valuable examples of the very type of clinically grounded theorizing that represents progress in self psychology. The opening section of clinical papers encompasses compensatory structures, facilitating responsiveness, repressed memories, mature selfobject experience, shame in the analyst, and the resolution of intersubjective impasses. Two self-psychologically informed approaches to supervision are followed by a section of contemporary explorations of sexuality. Contributions to therapy address transference and countertransference issues in drama therapy, an intersubjective approach to conjoint family therapy, and the (...) subjective worlds of profound abuse survivors. A concluding section of studies in applied self psychology round out this broad and illuminating survey of the field. (shrink)

Volume 17 of Progress in Self Psychology, _The Narcissistic Patient Revisited_, begins with the next installment of Strozier's "From the Kohut Archives": first publication of a fragment by Kohut on social class and self-formation and of four letters from his final decade. Taken together, Hazel Ipp's richly textured "Case of Gayle" and the commentaries that it elicits amount to a searching reexamination of narcissistic pathology and the therapeutic process. This illuminating reprise on the clinical phenomenology Kohut associated with "narcissistic personality (...) disorder" accounts for the volume title. The ability of modern self psychology to integrate central concepts from other theories gains expression in Teicholz's proposal for a two-tiered theory of intersubjectivity, in Brownlow's examination of the fear of intimacy, and in Garfield's model for the treatment of psychosis. The social relevance of self psychology comes to the fore in an examination of the experience of adopted children and an inquiry into the roots of mystical experience, both of which concern the ubiquity of the human longing for an idealized parent imago. Among contributions that bring self-psychological ideas to bear on the arts, Frank Lachmann's provocative "Words and Music," which links the history of music to the history of psychoanalytic thought in the quest for universal substrata of psychological experience, deserves special mention. Annette Lachmann's consideration of empathic failure among the characters in Shakespeare's _Othello_ and Silverstein's reflections on Schubert's self-states and selfobject needs in relation to the specific poems set to music in his Lieder round out a collection as richly broad based as the field of self psychology itself. (shrink)

_The Widening Scope of Self Psychology_ is a watershed in the self-psychological literature, being a contemporary reprise on several major clinical themes through which self psychology, from its inception, has articulated its challenge to traditional psychoanalytic thinking. The volume opens with original papers on interpretation by eminent theorists in the self-psychological tradition, followed by a series of case studies and clinically grounded commentaries bearing on issues of sex and gender as they enter into analysis. Two thoughtful reexaminations of the meaning (...) and treatment challenges of chronic rage are followed by clinical papers that focus, respectively, on mourning, alter ego transferences, resistance to change, and pathological identification. Applied analytic contributions and a review of Goldberg's _The_ _Prisonhouse of Psychoanalysis_ round out a collection that testifies not only to the widening scope of self psychology, but to its deepening insights as well. (shrink)

The tenth volume in the Progress in Self Psychology series begins with four timely assessments of the selfobject concept, followed by a section of clinical papers that span the topics of homosexuality, alter ego countertransference, hypnosis, trauma, dream theory, and intersubjective approaches to conjoint therapy. Section III, "A Dialogue of Self Psychology," offers Merton Gill's astute appreciation of "Heinz Kohut's Self Psychology," followed by commentaries by Leider and Stolorow and Gill's reply. The concluding section offers Stolorow and Atwood's "The Myth (...) of the Isolated Mind," followed by discussions by Gehrie and the Shanes. A forum for the kind of spirited, productive exchanges that have long found a home within the self-psychological community, _A Decade of Progress_ builds on the past in responding to the theoretical and clinical challenges of the present. (shrink)

_New Therapeutic Visions_ begins with Lachmann and Beebe's developmental perspectives on representational and selfobject transferences, followed by commentaries. In Section II, the self-psychological approach is brought to bear on the clinical treatment of an adolescent girl, incest survivors, addictive personalities, patients exhibiting codependency, and a case of desomatization. Section III, on applied self psychology, contains chapters on the theory of creativity; subjectivism, relativism, and realism in psychoanalysis; and quantum physics and self psychology. The final section offers two critical review essays (...) on major contributions to the self psychology literature by Wolf, by Bacal and Newman, and by Lichtenberg. Stolorow's chronicle of his personal odyssey into self psychology and intersubjectivity theory rounds out volume 8 of the Progress in Self Psychology series. (shrink)

Volume 12 of the Progress in Self Psychology series begins with reassessments of frustration and responsiveness, optimal and otherwise, by MacIsaac, Bacal and Thomson, the Shanes, and Doctors. The philosophical dimension of self psychology is addressed by Riker, who looks at Kohut's bipolar theory of the self, and Kriegman, who examines the subjectivism-objectivism dialectic in self psychology from the standpoint of evolutionary biology. Clinical studies focus on self- and mutual regulation in relation to therapeutic action, countertransference and the curative process, (...) and the consequences of the negative selfobject in early character formation. A separate section of child studies includes a case study exemplifying a self-psychological approach to child therapy and an examination of pathological adaptation to childhood parent loss. With a concluding section of richly varied studies in applied self psychology, _Basic Ideas Reconsidered_ promises to be basic reading for all students of contemporary self psychology. (shrink)

Debates over vaccine mandates raise intense emotions, as reflected in the current controversy over whether to mandate the vaccine against human papilloma virus (HPV), the virus that can cause cervical cancer. Public health ethics so far has failed to facilitate meaningful dialogue between the opposing sides. When stripped of its emotional charge, the debate can be framed as a contest between competing ethical values. This framework can be conceptualized graphically as a conflict between autonomy on the one hand, which militates (...) against government intrusion, and beneficence, utilitarianism, justice, and nonmaleficence on the other, which may lend support to intervention. When applied to the HPV vaccine, this framework would support a mandate based on utilitarianism, if certain conditions are met and if herd immunity is a realistic objective. (shrink)

The third volume in the distinguished Progress in Self Psychology series brings together the most exciting issues in a rapidly expanding field. _Frontiers in Self Psychology_ is highlighted by sections dealing with self psychology and infancy and self psychology and the psychoses. Clinical contributions include several case studies along with a reconsideration of dream interpretation. Theoretical contributions span issues of gender identity, boundary formation, and the biological foundation of self psychology.

Here we are witness to the great cultural event of the West, the emergence of a Latin philosophical language translated from the Greek. Once again, it would be necessary to make a systematic study of the formation of this technical vocabulary that, thanks to Cicero, Seneca, Tertullian, Victorinus, Calcidius, Augustine, and Boethius, would leave its mark, by way of the Middle Ages, on the birth of modern thought. Can it be hoped that one day, with current technical means, it will (...) be possible to compile a complete lexicon of the correspondences of philosophical terminology in Greek and Latin? Furthermore, lengthy commentaries would be needed, for the most interesting task would be to analyze the shifts in meaning that take place in the movement from one language to another. In the case of the ontological vocabulary the translation of ousia by substantia, for example, is justly famous and has again recently inspired some remarkable studies. This brings us once more to a phenomenon we discretely alluded to earlier with the word philosophia, and which we will encounter throughout the present discussion: the misunderstandings, shifts or losses in meaning, the reinterpretations, sometimes even to the point of misreading, that arise once tradition, translation, and exegesis coexist. So our history of the Hellenistic and Roman thought will consist above all of recognizing and analyzing the evolution of meanings and significance. Pierre Hadot holds the chair of the History of Hellenistic and Roman Thought at the Collège de France. He is the author of many books and articles on the history of ancient philosophy and theology. Among his works are Plotin et la simplicité du regard, Porphyre et Vitctorinus, Marius Victorinus: Recherches sur sa vie et ses oeuvres, and Exercises spirituels et philosophie antique. Arnold I. Davidson, executive editor of Critical Inquiry, is associate professor of philosophy and a member of the Committees on the Conceptual Foundations of Science and General Studies in the Humanities at the University of Chicago. He introduced and edited the “Symposium on Heidegger and Nazism” . He is currently working on the history of horror as it relates to the epistemology of norms and deviations. Paula Wissing, a free-lance translator and editor, has recently translated Marcel Detienne and Jean-Pierre Vernant’s The Cuisine of Sacrifice among the Greeks . She also contributed translations of articles by Maurice Blanchot, Philippe Lacoue-Labarthe, and Emmanuel Levinas for the “Symposium on Heidegger and Nazism.”. (shrink)

We think the present moment is a timely one for debating the relation between evidentiary protocols and academic disciplines. Since academic practices for constituting and deploying evidence tend to be discipline-specific, the much-discussed crisis of the disciplines in recent years has given rise to a series of controversies about the status of evidence in current modes of investigation and argument: deconstruction, gender studies, new historicism, cultural studies, new approaches to the history and philosophy of science, the critical legal studies movement, (...) and so on. Unfortunately, these controversies too often devolve into oversimplified debates about who has the evidence and who does not, who did their homework and who did not, or about the dangers of an ill-defined academic relativism. Attention needs to be better and otherwise directed: at the configuration of the fact-evidence distinction in different disciplines and historical moments, for example; or at the relative function of such notions as “self-evidence,” “experience,” “test,” “testimony,” and “textuality” in various academic discourses; or at the ways in which the invoked “rules of evidence” are themselves the products of historical developments, and themselves undergo redifferentiation and reformulation. James Chandler, professor of English at the University of Chicago, is the author of Wordsworth’s Second Nature . He is currently completing England in 1819, studies in and of romantic case history. Arnold I. Davidson, executive editor of Critical Inquiry, teaches philosophy and the history of science at the University of Chicago. He is currently working on the history of horror as it relates to the epistemology of norms and deviations and is editing a collection of essays on Heidegger, philosophy, and National Socialism. Harry Harootunian, a coeditor of Critical Inquiry and professor of history and East Asian languages and civilizations at the University of Chicago, is the author of Things Seen and Unseen: Discourse and Ideology in Tokigawa and editor, with Masao Miyoshi, of Postmodernism and Japan. (shrink)

I have two primary aims in the following paper, aims that are inextricably intertwined. First, I want to raise some historiographical and epistemological issues about how to write the history of psychoanalysis. Although they arise quite generally in the history of science, these issues have a special status and urgency when the domain is the history of psychoanalysis. Second, in light of the epistemological and methodological orientation that I am going to advocate, I want to begin a reading of Freud’s (...) Three Essays on the Theory of Sexuality, one whose specificity is a function of my attachment to this orientation, to a particular way of doing the history of psychoanalysis. Despite the enormous number of pages that have been written on Freud’s Three Essays, it is very easy to underestimate the density of this book, a density at once historical, rhetorical, and conceptual. This underestimation stems in part from historiographical presumptions that quite quickly misdirect us away from the fundamental issues.In raising question about the historiography of the history of science, I obviously cannot begin at the beginning. So let me begin much further along, with the writings of Michel Foucault. I think of the works of Foucault, in conjunction with that of Gaston Bachelard and Georges Canguilhem, as exemplifying a very distinctive perspective about how to write the history of science. In the English-speaking world, perhaps only the work of Ian Hacking both shares this perspective and ranks with its French counterparts in terms of originality and quality. No brief summary can avoid eliding the differences between Bachelard, Canguilhem, Hacking, and Foucault; indeed, the summary I am going to produce does not even fully capture Foucault’s perspective, which he called “archaeology.”1 But this sketch will have to do for the purposes I have in mind here, whose ultimate aim is to reorient our approach to the history of psychoanalysis. 1. The sketch that follows reproduces, with some omissions and additions, the beginning of my “Archeology, Genealogy, Ethics,” in Michel Foucault: A Critical Reader, ed. David Hoy , pp. 221-34. Arnold I. Davidson is assistant professor in the department of philosophy, the Committee on the Conceptual Foundations of Science, and the Committee on General Studies in the Humanities at the University of Chicago. He is currently writing a book on the history and epistemology of nineteenth-century psychiatric theories of sexuality. (shrink)

Recent interpretations of Locke's primary/secondary quality distinction have tended to emphasize Locke's relationship to the corpuscularian science of his time, especially to that of Boyle. Although this trend may have corrected the unfortunate tendency to view Locke in isolation from his scientific contemporaries, it nevertheless has resulted in some over- simplifications and distortions of Locke's general enterprise. As everyone now agrees, Locke was attempting to provide a philosophical foundation for English corpuscularianism and one must therefore look not only at the (...) current scientific hypotheses but also at the nature of the philosophical foundation Locke was attempting to erect. In particular, Locke made an attempt, based on epistemological principles, to give a philosophical justification of atomistic corpuscularianism. Moreover, he was not content to give this justification post hoc—the epistemological foundation was prior to, and determined the framework for, the details of the correct scientific theory. Locke's epistemology made legitimate an atomistic theory, one making crucial use of the notion of solidity in the definition of the elementary particles, although it did not prejudge the details of this theory. (shrink)

Perhaps the question “What is philosophy?” can only be posed late in life, when old age has come, and with it the time to speak in concrete terms. It is a question one poses when one no longer has anything to ask for, but its consequences can be considerable. One was asking the question before, one never ceased asking it, but it was too artificial, too abstract; one expounded and dominated the question, more than being grabbed by it. There are (...) cases in which old age bestows not an eternal youth, but on the contrary a sovereign freedom, a pure necessity where one enjoys a moment of grace between life and death, and where all the parts of the machine combine to dispatch into the future a trait that traverses the ages: Turner, Monet, Matisse. The elderly Turner acquired or conquered the right to lead painting down a deserted path from which there was no return, and that was no longer distinguishable from a final question. In the same way, in philosophy, Kant’s Critique of Judgment is a work of old age, a wild work from which descendants will never cease to flow.We cannot lay claim to such a status. The time has simply come for us to ask what philosophy is. And we have never ceased to do this in the past, and we already had the response, which has not varied: philosophy is the art of forming, inventing, and fabricating concepts. But it was not only necessary for the response to take note of the question; it also had to determine a time, an occasion, the circumstances, the landscapes and personae, the conditions and unknowns of the question. One had to be able to pose the question “between friends” as a confidence or a trust, or else, faced with an enemy, as a challenge, and at the same time one had to reach that moment, between dog and wolf, when one mistrusts even the friend. Gilles Deleuze was professor of philosophy at the University of Paris VIII, Vincennes-St.-Denis, until his retirement in 1987. Among his books translated into English are the two-volume Capitalism and Schizophrenia , the two-volume Cinema , The Logic of Sense , and Expressionism in Philosophy: Spinoza . Daniel W. Smith is a doctoral candidate in philosophy at the University of Chicago. He is at work on a study of the philosophy of Deleuze, and is translating Deleuze’s Francis Bacon: Logique de la sensation. Arnold I. Davidson, executive editor of Critical Inquiry, teaches philosophy at the University of Chicago and is currently Marta Sutton Weeks Fellow at the Stanford Humanities Center. (shrink)

One of the traditional ways mathematical ideas and even new areas of mathematics are created is from experiments. One of the best-known examples is that of the Fermat hypothesis, which was conjectured by Fermat in his attempts to find integer solutions for the famous Fermat equation. This hypothesis led to the creation of a whole field of knowledge, but it was proved only after several hundred years. This book, based on the author's lectures, presents several new directions of mathematical research. (...) All of these directions are based on numerical experiments conducted by the author, which led to new hypotheses that currently remain open, i.e., are neither proved nor disproved. The hypotheses range from geometry and topology (statistics of plane curves and smooth functions) to combinatorics (combinatorial complexity and random permutations) to algebra and number theory (continuous fractions and Galois groups). For each subject, the author describes the problem and presents numerical results that led him to a particular conjecture. In the majority of cases there is an indication of how the readers can approach the formulated conjectures (at least by conducting more numerical experiments). Written in Arnold's unique style, the book is intended for a wide range of mathematicians, from high school students interested in exploring unusual areas of mathematics on their own, to college and graduate students, to researchers interested in gaining a new, somewhat nontraditional perspective on doing mathematics. In the interest of fostering a greater awareness and appreciation of mathematics and its connections to other disciplines and everyday life, MSRI and the AMS are publishing books in the Mathematical Circles Library series as a service to young people, their parents and teachers, and the mathematics profession. Titles in this series are co-published with the Mathematical Sciences Research Institute (MSRI). (shrink)

The recent review by Monrad1 presents several issues about secondary vaccine trials. It lays out the case in which a vaccine has been tested through phases I–III and is being deployed. Subsequently, consideration is being given to conducting ‘trials for another vaccine for the pathogen’. Monrad states: ‘In summary, we may say that researchers have strong prima facie reasons not to conduct a secondary vaccine trial.’ Monrad discusses several factors meriting careful consideration about the need for developing and testing more (...) than one vaccine: relative efficacy, length of immunity, adverse reactions, ease of storage and administration, economic and logistical factors. What is not addressed are the ethical duties that exist when there are competing phase III vaccine candidates for COVID-19. We have serious concerns about potential ethical inadequacies about these ongoing trials and …. (shrink)

Activation of the brainʼs putative retinoid system has been proposed as the neuronal substrate for our basic sense of being centered within a volumetric surround –- our minimal phenomenal consciousness (Trehub 2007). Here, the assumed properties of the self-locus within the retinoid model are shown to explain recent experimental findings relating to the out-of-body-experience. In addition, selective excursion of the heuristic self-locus is able to explain many important functions of consciousness, including the effective internal representation of a 3D space on (...) the basis of 2D perspective depictions. Our sense of self-agency is shown to be a natural product of the role of the heuristic self-locus in the retinoid mechanism. (shrink)